Breast Cancer With Brain Metastases: Perspective From a Long-Term Survivor
Identifieur interne : 000200 ( an2020/Analysis ); précédent : 000199; suivant : 000201Breast Cancer With Brain Metastases: Perspective From a Long-Term Survivor
Auteurs : Christopher P. Kofron [États-Unis] ; Angela Chapman [États-Unis]Source :
- Integrative Cancer Therapies [ 1534-7354 ] ; 2020.
Abstract
The purpose of this essay is to inform others that it is possible to survive breast cancer with brain metastases. The second author is the subject patient and a long-term survivor of systemic metastatic breast cancer with numerous brain metastases (corresponding to 8% survivor group). We credit her survival to a combination of (1) medicine as practiced by an excellent oncologist with whom we developed a partnership to manage the patient’s health, (2) our informed exploration of the available scientific knowledge including a review of scientific research articles that go beyond conventional care, and (3) the patient’s supplementation with numerous repurposed drugs and other substances reported to have antitumor properties. Alongside her conventional treatment (the medical standard of care), it seems likely that this supplementation has been a key factor in the patient’s long-term survival. We also point out that the lack of follow-up magnetic resonance imaging brain scans for early detection of brain metastases poses substantial risks for patients with HER2+ metastatic breast cancer in non–central nervous system locations. Thus, we suggest that research be conducted on such early detection for possible inclusion in the recommendations for the medical standard of care. Finally, medical doctors and also patients with backgrounds in biological science may wish to consider potential options and advantages of repurposed drugs and other substances reported in scientific publications when the medical standard of care has limited options for advanced cancer and other severe chronic health conditions. However, any efforts along this line by patients should be in collaboration with their medical doctors.
Url:
DOI: 10.1177/1534735419890017
PubMed: 31906724
PubMed Central: 6947880
Affiliations:
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Kofron</name><affiliation wicri:level="1"><nlm:aff id="aff1-1534735419890017">US Fish and Wildlife Service, Ventura, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>US Fish and Wildlife Service, Ventura, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Chapman, Angela" sort="Chapman, Angela" uniqKey="Chapman A" first="Angela" last="Chapman">Angela Chapman</name><affiliation wicri:level="1"><nlm:aff id="aff2-1534735419890017">Biology Program, California State University Channel Islands, Camarillo, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biology Program, California State University Channel Islands, Camarillo, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author></analytic><series><title level="j">Integrative Cancer Therapies</title><idno type="ISSN">1534-7354</idno><idno type="eISSN">1552-695X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The purpose of this essay is to inform others that it is possible to survive breast cancer with brain metastases. The second author is the subject patient and a long-term survivor of systemic metastatic breast cancer with numerous brain metastases (corresponding to 8% survivor group). We credit her survival to a combination of (1) medicine as practiced by an excellent oncologist with whom we developed a partnership to manage the patient’s health, (2) our informed exploration of the available scientific knowledge including a review of scientific research articles that go beyond conventional care, and (3) the patient’s supplementation with numerous repurposed drugs and other substances reported to have antitumor properties. Alongside her conventional treatment (the medical standard of care), it seems likely that this supplementation has been a key factor in the patient’s long-term survival. We also point out that the lack of follow-up magnetic resonance imaging brain scans for early detection of brain metastases poses substantial risks for patients with HER2+ metastatic breast cancer in non–central nervous system locations. Thus, we suggest that research be conducted on such early detection for possible inclusion in the recommendations for the medical standard of care. Finally, medical doctors and also patients with backgrounds in biological science may wish to consider potential options and advantages of repurposed drugs and other substances reported in scientific publications when the medical standard of care has limited options for advanced cancer and other severe chronic health conditions. However, any efforts along this line by patients should be in collaboration with their medical doctors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kohler, Ba" uniqKey="Kohler B">BA Kohler</name></author><author><name sortKey="Sherman, Rl" uniqKey="Sherman R">RL Sherman</name></author><author><name sortKey="Howlader, N" uniqKey="Howlader N">N Howlader</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kodack, Dp" uniqKey="Kodack D">DP Kodack</name></author><author><name sortKey="Askoxylakis, V" uniqKey="Askoxylakis V">V Askoxylakis</name></author><author><name sortKey="Ferraro, Gb" uniqKey="Ferraro G">GB Ferraro</name></author><author><name sortKey="Fukumura, D" uniqKey="Fukumura D">D Fukumura</name></author><author><name sortKey="Jain, Rk" uniqKey="Jain R">RK. 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Brufsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guth, U" uniqKey="Guth U">U Güth</name></author><author><name sortKey="Elfgen, C" uniqKey="Elfgen C">C Elfgen</name></author><author><name sortKey="Montagna, G" uniqKey="Montagna G">G Montagna</name></author><author><name sortKey="Schmid, Sm" uniqKey="Schmid S">SM. Schmid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dietrich, J" uniqKey="Dietrich J">J Dietrich</name></author><author><name sortKey="Baryawno, N" uniqKey="Baryawno N">N Baryawno</name></author><author><name sortKey="Nayyar, N" uniqKey="Nayyar N">N Nayyar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dadwal, P" uniqKey="Dadwal P">P Dadwal</name></author><author><name sortKey="Mahmud, N" uniqKey="Mahmud N">N Mahmud</name></author><author><name sortKey="Sinai, L" uniqKey="Sinai L">L Sinai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ayoub, R" uniqKey="Ayoub R">R. Ayoub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, U" uniqKey="Patel U">U Patel</name></author><author><name sortKey="Patel, A" uniqKey="Patel A">A Patel</name></author><author><name sortKey="Cobb, C" uniqKey="Cobb C">C Cobb</name></author><author><name sortKey="Benkers, T" uniqKey="Benkers T">T Benkers</name></author><author><name sortKey="Vermeulen, S" uniqKey="Vermeulen S">S. Vermeulen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kofron, Christopher P" sort="Kofron, Christopher P" uniqKey="Kofron C" first="Christopher P." last="Kofron">Christopher P. Kofron</name></noRegion><name sortKey="Chapman, Angela" sort="Chapman, Angela" uniqKey="Chapman A" first="Angela" last="Chapman">Angela Chapman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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